A new simple, sensitive, rapid, accurate, precise and economical dual wavelength Spectrophotometric method for the simultaneous determination of Levosulpiride (LEVO) and Pantoprazole sodium (PANTO) in combined capsule dosage form was developed. The dual wavelength Spectrophotometric method was based the absorbance of the solutions were measured at 232.32 nm (λ1), 295 nm (λ2¬), 264 nm (λ3), 270 nm (λ4) for the estimation of both the drugs. The quantitative determination of LEVO is carried out by measuring absorbance difference between 232.32 nm and 295 nm and for PANTO by absorbance difference at 264 nm and 270 nm. The linearity was obtained in the concentration range of 15-90 μg/ml for LEVO and 8-48 μg/ml for PANTO The mean recovery was 98.44 –100.36% and 98.33 – 101.25% for LEVO and PANTO respectively. The results of analysis have been validated statistically as per ICH guidelines.
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